Glassy state of pharmaceuticals. IV. Studies on glassy pharmaceuticals by thermomechanical analysis.
نویسندگان
چکیده
منابع مشابه
Quantifying the Structural Dynamics of Pharmaceuticals in the Glassy State.
Structural dynamics in the glassy state of two protic ionic liquids, carvedilol phosphate and procaine hydrochloride, were characterized from analysis of changes in the conductivity relaxation times during physical aging. The obtained relaxation times, having a magnitude exceeding feasible experimental time scales and thus not directly measurable, are consistent with published data from a metho...
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Bioinequivalence of glassy and crystalline indomethacin was investigated in rabbits. In vivo absorption studies were carried out by determining the plasma levels of indomethacin following oral and rectal administrations in rabbits. The A UC (area under the concentration–time curve) and the maximum plasma level following the administration of the glassy preparation were larger than those in the ...
متن کاملSulfadiazine Determination in Pharmaceuticals by Electrochemical Reduction on a Glassy Carbon Electrode
Sulfadiazina foi quantificada em duas amostras de produtos farmacêuticos usando voltametria de onda quadrada. O sinal analítico foi obtido por redução em vez de oxidação da sulfa sobre eletrodo de carbono vítreo. A determinação eletroanalítica foi realizada em solução-tampão Britton-Robinson 0,04 mol L com pH 6,8. A redução irreversível da sulfadiazina foi observada em –1,49 V vs. Ag/AgCl. A cu...
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Poly-Carbonate (PC) and Poly-Methyl-Methacrylate (PMMA) are lightweight and mechanically tough transparent glassy polymers. Their mechanical behavior at low to moderate strain rates has been well characterized; however, that at high strain rates needs additional work. We propose two modifications to existing pressure-dependent viscoplastic constitutive equations that enable one to simulate bett...
متن کاملHeterogeneities in the glassy state.
We study heterogeneities in a binary Lennard-Jones system below the glass transition using molecular dynamics simulations. We identify mobile and immobile particles and measure their distribution of vibrational amplitudes. For temperatures near the glass transition the distribution of vibrational amplitudes obeys scaling and compares reasonably well with a mean-field theory for the amorphous so...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1989
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.37.2782